There have been no confirmed reports of drug interactions. However, because of the neuro-receptor activities of sceletium tortuosum there may be interactions with other pharmacokinetic drugs. People taking any psychiatric drug (including all anti-anxiety drugs, sedatives, hypnotics, anti-depressants and anti-psychotics and so-called “designer” or recreational drugs) or any cardiac medications, are advised not to take sceletium tortuosum-containing products without their medical doctors assistance. As with most supplements and modern drugs, safety in pregnancy for Release Sce has not been established.